- Department of Chemistry and Biochemistry
- University of California San Diego
- 9500 Gilman Drive
- San Diego, CA 92093, USA
- email: email@example.com
- github: kaizhang
- website: https://kzhang.org
I develop and apply systems biology approaches to study gene regulation. Specifically, I utilize genomics, epigenomics and single-cell genomics data to study transcriptional regulatory elements, construct gene regulatory networks and identify driver genes in different diseases and biological processes.
Ph.D., Bioinformatics and Systems Biology, University of California San Diego, CA
- Thesis: Novel network-based integrated analyses of multi-omics data reveal new insights into CD8+ T cell differentiation and mouse embryogenesis
- Advisor: Wei Wang
M.S., Biochemistry and Molecular Biology, Xiamen University, China
- Fields: Transcriptional elongation, signal transduction.
Research Assistant, Bioinformatics and Systems Biology Program, University of California San Diego.
Research Assistant, Department of Biochemistry, National University of Singapore, Singapore.
Research Assistant, Department of Biochemistry, Xiamen University, China.
Zhang, K., Wang, M., Zhao, Y., and Wang, W. Systems-level identification of key transcription factors reveals transcriptional waves in mouse embryonic development. ▶Science Advances.
Ngo, V., Chen, Z., Zhang, K., Whitaker J., Wang, M., Wang, W. Epigenomic analysis reveals DNA motifs regulating histone modifications in human and mouse. ▶PNAS.
Fan, S., Tang, J., Li, N., Zhao, Y., Ai, R., Zhang, K., Wang, M., Du, W., and Wang, W. Integrative analysis with expanded DNA methylation data reveals common key regulators and pathways in cancers. ▶Npj Genomic Medicine.
Wei, W., Ji, Z., He, Y., Zhang, K., Ha, Y., Li, Q., and Ohno-Machado, L. Finding relevant biomedical datasets: the UC San Diego solution for the bioCADDIE Retrieval Challenge. ▶Database.
Ainsworth, R., Ai, R., Ding, B., Li, N., Zhang, K., and Wang, W. Bayesian Networks Predict Neuronal Transdifferentiation. ▶G3 Genes Genomes Genetics.
Milner, J., Toma, C., Yu, B., Zhang, K., Omilusik, K., Phan, A., Wang, D., Getzler, A., Nguyen, T., Crotty, S., et al. Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours. ▶Nature.
Yu, B.*, Zhang, K.*, Milner, J., Toma, C., Chen, R., Scott-Browne, J., Pereira, R., Crotty, S., Chang, J., Pipkin, M., et al. Epigenetic landscapes reveal transcription factors that regulate CD8+ T cell differentiation. ▶Nature Immunology. (* co-first authors)
Zhang, K., Li, N., Ainsworth, R., and Wang, W. Systematic identification of protein combinations mediating chromatin looping. ▶Nature Communications.
Zhu, Y., Chen, Z., Zhang, K., Wang, M., Medovoy, D., Whitaker, J., Ding, B., Li, N., Zheng, L., and Wang, W. Constructing 3D interaction maps from 1D epigenomes. ▶Nature Communications.
Chen, R., Liu, M., Zhang, K., and Zhou, Q. Isolation and functional characterization of P-TEFb-associated factors that control general and HIV-1 transcriptional elongation. ▶Methods.
Ai, N., Hu, X., Ding, F., Yu, B., Wang, H., Lu, X., Zhang, K., Li, Y., Han, A., Lin, W., et al. Signal-induced Brd4 release from chromatin is essential for its role transition from chromatin targeting to transcriptional regulation. ►Nucleic Acids Res.
Honors and awards
Doctoral fellowship, Frontiers of Innovation Scholars Program (FISP), UC San Diego.
Doctoral fellowship, Dr. Huang Memorial Scholarship, UC San Diego.
Peer Review Activities
- Journal: Database, Journal of Integrative Bioinformatics, Mutation Research: Fundamental and Molecular Mechanisms of Mutagenesis.