Curriculum Vitae

Kai Zhang

Personal data

  • Department of Chemistry and Biochemistry
  • University of California San Diego
  • 9500 Gilman Drive
  • San Diego, CA 92093, USA
  • email: kai@kzhang.org
  • github: kaizhang
  • website: https://kzhang.org

Research interests

I develop and apply systems biology approaches to study gene regulation. Specifically, I utilize genomics, epigenomics and single-cell genomics data to study transcriptional regulatory elements, construct gene regulatory networks and identify driver genes in different diseases and biological processes.

Education

Ph.D., Bioinformatics and Systems Biology, University of California San Diego, CA

  • Thesis: Novel network-based integrated analyses of multi-omics data reveal new insights into CD8+ T cell differentiation and mouse embryogenesis
  • Advisor: Wei Wang
2018

M.S., Biochemistry and Molecular Biology, Xiamen University, China

  • Fields: Transcriptional elongation, signal transduction.
2012
B.S., Biological Science, Xiamen University, China
2009

Research experience

Research Assistant, Bioinformatics and Systems Biology Program, University of California San Diego.

2013 - 2018

Research Assistant, Department of Biochemistry, National University of Singapore, Singapore.

2012

Research Assistant, Department of Biochemistry, Xiamen University, China.

2008 - 2012

Publications

A list is also available online.

Peer-Reviewed Articles

Zhang, K., Wang, M., Zhao, Y., and Wang, W. Systems-level identification of key transcription factors reveals transcriptional waves in mouse embryonic development. ▶Science Advances.

forthcoming

Ngo, V., Chen, Z., Zhang, K., Whitaker J., Wang, M., Wang, W. Epigenomic analysis reveals DNA motifs regulating histone modifications in human and mouse. ▶PNAS.

forthcoming

Fan, S., Tang, J., Li, N., Zhao, Y., Ai, R., Zhang, K., Wang, M., Du, W., and Wang, W. Integrative analysis with expanded DNA methylation data reveals common key regulators and pathways in cancers. ▶Npj Genomic Medicine.

forthcoming

Wei, W., Ji, Z., He, Y., Zhang, K., Ha, Y., Li, Q., and Ohno-Machado, L. Finding relevant biomedical datasets: the UC San Diego solution for the bioCADDIE Retrieval Challenge. ▶Database.

2018

Ainsworth, R., Ai, R., Ding, B., Li, N., Zhang, K., and Wang, W. Bayesian Networks Predict Neuronal Transdifferentiation. ▶G3 Genes Genomes Genetics.

2018

Milner, J., Toma, C., Yu, B., Zhang, K., Omilusik, K., Phan, A., Wang, D., Getzler, A., Nguyen, T., Crotty, S., et al. Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours. ▶Nature.

2017

Yu, B.*, Zhang, K.*, Milner, J., Toma, C., Chen, R., Scott-Browne, J., Pereira, R., Crotty, S., Chang, J., Pipkin, M., et al. Epigenetic landscapes reveal transcription factors that regulate CD8+ T cell differentiation. ▶Nature Immunology. (* co-first authors)

2017

Zhang, K., Li, N., Ainsworth, R., and Wang, W. Systematic identification of protein combinations mediating chromatin looping. ▶Nature Communications.

2016

Zhu, Y., Chen, Z., Zhang, K., Wang, M., Medovoy, D., Whitaker, J., Ding, B., Li, N., Zheng, L., and Wang, W. Constructing 3D interaction maps from 1D epigenomes. ▶Nature Communications.

2016

Chen, R., Liu, M., Zhang, K., and Zhou, Q. Isolation and functional characterization of P-TEFb-associated factors that control general and HIV-1 transcriptional elongation. ▶Methods.

2011

Ai, N., Hu, X., Ding, F., Yu, B., Wang, H., Lu, X., Zhang, K., Li, Y., Han, A., Lin, W., et al. Signal-induced Brd4 release from chromatin is essential for its role transition from chromatin targeting to transcriptional regulation. ►Nucleic Acids Res.

2011

Honors and awards

Doctoral fellowship, Frontiers of Innovation Scholars Program (FISP), UC San Diego.

2015

Doctoral fellowship, Dr. Huang Memorial Scholarship, UC San Diego.

2012-2014

Professional service

Peer Review Activities

  • Journal: Database, Journal of Integrative Bioinformatics, Mutation Research: Fundamental and Molecular Mechanisms of Mutagenesis.